see Instructions below
JME
Editor courtesy of Peter Ertl, Novartis
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Useful Commands in JSmol: 1) ALT + mouse drag --> rotate on the screen x y plane 2) CTRL+ ALT + drag mouse --> move horizontally / vertically on the screen x y plane 3) using mouse wheel --> increase / reduce zoom 4) mouse --> rotate in the three dimensions
Background Color
Choose the Priority
Choose: R / S?
Check your Answer
Mostra tutti i Carboni Chirali
Instructions and Rules:
1) to assign priority, click on"Initialize".
2) click on the chiral carbon in JSMol and after click on "Chiral Carbon" button
3) repeat the step 2 for each atom directly linked to the Chiral Carbon to assign CIP Priority
4) orientate the molecule properly, with the priority 4 group point away from you
5) assign the chirality, R or S, by clicking on the chiral carbon and after on the proper "R" or "S" button
6) check your answer by clicking on the "Check Chirality" button
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Enantiomers
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Sequence Rules
Sequence Rules
Assign the priority order to the susbtituents on the asymmetric carbon according to the Cahn-Ingold-Prelog rules.
- For every substituent, look at the first atom linked to the asymmetric carbon: the atom having the highest atomic number has the highest priority
- If it is not possible to define all the priorities in this way, look at the second atom away form the double bond carbon atom, and so on, until a point of difference can be found.
- The atoms having multiple bonds are equivalents to the same number of atoms linked by single bonds.
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Correct Orientation of the Molecule
Correct Orientation of the Molecule - 2
Orient the molecule with the lowest priority group (4) back, away from the observer.
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Configuration Assignment
Configuration Assignment - 3
Observe the sequence 1 ---> 2 ---> 3. If, in order to follow the correct order the rotation is:
1) clockwise, the configuration is R
2) counterclockwise, the configuration is S